Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals.

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

As language models learn to interpret words in a sentence, protein language models learn how amino acids work together within ...

A new gene-editing technique enables the correction of multiple genetic mutations simultaneously, transforming the prospects ...

Researchers at Baylor College of Medicine have discovered that certain p53 mutants hijack the DNA replication machinery ...

King’s College London researchers discovered that parts of our DNA once thought to be “junk” can actually help destroy cancer cells. In some blood cancers, damaged genes trigger chaos in these DNA ...

Bowhead whales, living over two centuries, defy cancer risks due to exceptional DNA repair, not more tumor suppressors.

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

A new study maps out the timeline of DNA damage for multiple myeloma, the second most common blood cancer. The findings may lead to better ways to group patients by the state of their DNA and define ...

Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists from the German Cancer Research Center (DKFZ) and the Universities of Cambridge and ...